1: 91 percent / aq. NaOH / methanol / 19 h / Ambient temperature 2: 58 percent / H2O / 19 h / Ambient temperature; adenosine deaminase type I View Scheme

1: 1.) HF, pyridine, tert-butyl nitrite, 2.) aq. NaHCO3 / 1.) -20 deg C, 3 h, 2.) 20 min 2: 74 percent / NaHCO3 / methanol / 2.5 h / Ambient temperature 3: 1.) 1,1'-(thiocarbonyl)diimidazole, 2.) AIBN, tri-n-butyltin hydride / 1.) acetonitrile, 45 deg C, 24 h, 2.) toluene, reflux, 1 h 4: 73 percent / aq. LiOH / methanol / 7 h / Ambient temperature View Scheme

With  hydrogen; palladium on activated charcoal in  ethanol P=760 Torr; 5 h;   

Multi-step reaction with 2 steps 1: 72 percent / aq. NaN3 / ethanol / 0.5 h / Heating2: 80 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr