反应条件
1: (tert-butoxycarbonylmethyl)-triphenylphosphonium bromide; phthalic carbaldehyde With sodium hydroxide in dichloromethane; water T=-5 - -3°C; 2.75 h; Industry scale; 2: 3-amino-2-butenoic acid ethyl ester With trifluoroacetic acid in isopropyl alcohol T=-7°C; 2.75 h; 3: With sodium hydrogencarbonate in water; ethyl acetate; isopropyl alcohol T=0 - 25°C; 0.333333 h;
参考文献
Sajja, Eswaraiah; Vetukuri, Venkata Naga Kali Vara Prasada Raju; Ningam, Srinivas Reddy; Vedantham, Ravindra
Patent: US2007/43088 A1, 2007 ;
Location in patent: Page/Page column 6 ;
