1: 89 percent / aqu. HF, pyridine / acetonitrile 2: 98 percent / Al(Hg) / tetrahydrofuran; H2O 3: enzyme View Scheme

1: 78 percent / pyridine, 50percent aq. HF / 1.) 0 deg C, 30 min; 2.) rt, 4.5 h 2: aluminum amalgam / tetrahydrofuran; H2O / addition in equal portion after 10 h, 17 h and 23h; rt 15 h View Scheme