4-二甲基氨基甲基-6-氟-2-甲氧基苯酚合成路线 （共 6 条）
反应条件
in ethanol 2 h; Heating;
参考文献
Clark, Michael T.; Miller, Duane D.
Journal of Organic Chemistry, 1986 , vol. 51, # 21 p. 4072 - 4073
反应条件
formaldehyd in ethanol
参考文献
Ohio State University Research Foundation
Patent: US4737504 A1, 1988 ;
US 4737504 A
反应条件
in ethanol; water 2 h; Heating;
参考文献
Clark, Michael T.; Adejare, Adeboye; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 86 - 90
反应条件
2: 87 percent / ethanol; H2O / 42 h / 25 °C View Scheme
参考文献
Kawase; Sinhababu; McGhee; Milby; Borchardt
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2204 - 2211
反应条件
1: 1.) MeI / 1.) CHCl3, 25 deg C, 18 h, 2.) DMSO, 25 deg C, 7 h 2: 90.1 percent / BBr3 / CH2Cl2 / 18 h / 25 °C View Scheme
参考文献
Clark, Michael T.; Adejare, Adeboye; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 86 - 90
反应条件
Yield given. Multistep reaction;
参考文献
Lim, Kwang Su; Lee, Hobin; Kim, Sung Eun; Ha, Tae-Hwan; Ann, Jihyae; Son, Karam; Choi, Sun; Sun, Wei; Pearce, Larry V.; Deandrea-Lazarus, Ian A.; Blumberg, Peter M.; Lee, Jeewoo
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 233 - 243
