4-氨基-3-羟基-1-萘羧酸合成路线 （共 6 条）
反应条件
1: With 4-DBSA; sodium hydrogencarbonate T=60°C; 2: With sodium hydrogensulfite T=50°C; 0.5 h; Further stages.;
参考文献
SmithKline Beecham Corporation; Ligand Pharmaceuticals
Patent: US6670387 B1, 2003 ;
Location in patent: Page column 19 ;
反应条件
1.1: 90 percent / 10percent aq. NaOH; H2 / 10percent Pd/C / 4 h / 20 °C / 2585.81 Torr 2.1: 74 percent / aq. H2SO4; NaNO2 / 10 °C 3.1: p-diazoniumbenzenesulfonate; aq. NaHCO3 / 60 °C 3.2: 15 percent / NaHSO3 / 0.5 h / 50 °C View Scheme
参考文献
Duffy; Darcy; Delorme; Dillon; Eppley; Erickson-Miller; Giampa; Hopson; Huang; Keenan; Lamb; Leong; Liu; Miller; Price; Rosen; Shah; Shaw; Smith; Stark; Tian; Tyree; Wiggall; Zhang; Luengo
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3730 - 3745
反应条件
1.1: aq. NaOH; HgO; glacial AcOH / 72 h / Heating 1.2: aq. HCl / 4 h / Heating 2.1: 90 percent / 10percent aq. NaOH; H2 / 10percent Pd/C / 4 h / 20 °C / 2585.81 Torr 3.1: 74 percent / aq. H2SO4; NaNO2 / 10 °C 4.1: p-diazoniumbenzenesulfonate; aq. NaHCO3 / 60 °C 4.2: 15 percent / NaHSO3 / 0.5 h / 50 °C View Scheme
参考文献
Duffy; Darcy; Delorme; Dillon; Eppley; Erickson-Miller; Giampa; Hopson; Huang; Keenan; Lamb; Leong; Liu; Miller; Price; Rosen; Shah; Shaw; Smith; Stark; Tian; Tyree; Wiggall; Zhang; Luengo
Journal of Medicinal Chemistry, 2001 , vol. 44, # 22 p. 3730 - 3745
反应条件
Reduktion des erhaltenen Farbstoffs mit alkal. Na2S2O4-Loesung;
参考文献
Lesser; Gad
Chemische Berichte, 1925 , vol. 58, p. 2556
参考文献
Lesser; Gad
Chemische Berichte, 1925 , vol. 58, p. 2556
反应条件
anhydrous copper sulphate; water; copper(II) sulfate; sodium nitrite
Diazotization;
参考文献
Lesser; Gad
Chemische Berichte, 1925 , vol. 58, p. 2556
