3,4-二氯-2-甲基吡啶合成路线 （共 5 条）
反应条件
hydrogenchloride; sodium nitrite 1) 0 to 5 deg C, 1 h, 2) 25 deg C, 2 h;
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
1: 64 percent / Cl2, H2SO4 / 2 h / 0 °C 2: 96 percent / NaNO2, conc. HCl / 1) 0 to 5 deg C, 1 h, 2) 25 deg C, 2 h View Scheme
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=20 - 25°C; 16 h;
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
反应条件
3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride in methanol; dichloromethane
参考文献
SMITH KLINE and FRENCH LABORATORIES, LIMITED
Patent: EP184322 A1, 1986 ;
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 16 h / 20 - 25 °C
2: trifluoroacetic anhydride / 2 h / 15 - 20 °C
View Scheme
参考文献
Ife; Dyke; Keeling; Meenan; Meeson; Parsons; Price; Theobald; Underwood
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1970 - 1977
