1-碘-4-(三氟甲氧基)苯合成路线 （共 12 条）
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: With iodine in tetrahydrofuran; diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
hydrogenchloride; potassium iodide; iodine; sodium nitrite in water
反应条件
hydrogenchloride; potassium iodide; iodine; sodium nitrite in water
反应条件
CuO-supported Pd(0) nanoparticles in N,N-dimethyl-formamide T=120°C; 12 h;
参考文献
Chattopadhyay, Kalicharan; Dey, Raju; Ranu, Brindaban C.
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3164 - 3167
反应条件
potassium tert-butylate; phenylhydrazine T=100°C; 30 h; Inert atmosphereSchlenk technique;
参考文献
Organic Letters, , vol. 15, # 23 p. 6102 - 6105
反应条件
n-butyllithium; pyridinium chlorochromate in diethyl ether; hexane; dichloromethane; chloroform; acetic acid; ethyl acetate
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP174769 B1, 1991 ;
反应条件
1: triethylamine; copper(l) iodide / Pd2(PPh3)2Cl2 / tetrahydrofuran / 3 h / 20 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
MERCK and CO., INC.
Patent: WO2008/133867 A1, 2008 ;
反应条件
1,10-phenanthroline; potassium tert-butylate
T=100°C; 24 h; Inert atmosphereSealed tube;
参考文献
Sun, Chang-Liang; Li, Hu; Yu, Da-Gang; Yu, Miao; Zhou, Xiao; Lu, Xing-Yu; Huang, Kun; Zheng, Shu-Fang; Li, Bi-Jie; Shi, Zhang-Jie
Nature Chemistry, 2010 , vol. 2, # 12 p. 1044 - 1049
反应条件
potassium tert-butylate; phenylhydrazine
T=100°C; 30 h; Inert atmosphereSchlenk technique;
参考文献
Dewanji, Abhishek; Murarka, Sandip; Curran, Dennis P.; Studer, Armido
Organic Letters, 2013 , vol. 15, # 23 p. 6102 - 6105
反应条件
1: 1-{6-[dibutyl(phenyl)stannyl]hexyl}-3-methyl-1H-imidazolium iodide With tris(dibenzylideneacetone)dipalladium(0) chloroform complex
T=35°C; Stille coupling; 0.25 h; Inert atmosphereneat (no solvent);
2: 4-(trifluoromethoxy)-iodobenzene T=35°C; Stille coupling; 24 h; Inert atmosphereneat (no solvent);
参考文献
Pham, Phuoc Dien; Vitz, Juergen; Chamignon, Cecile; Martel, Arnaud; Legoupy, Stephanie
European Journal of Organic Chemistry, 2009 , # 19 p. 3249 - 3257
