1-碘-4-(三氟甲氧基)苯合成路线 （共 12 条）
反应条件
tetrabutylammomium bromide; silver(I) acetate; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide
T=120°C; 18 h; Molecular sieveInert atmosphere;
参考文献
Saha, Debasree; Adak, Laksmikanta; Ranu, Brindaban C.
Tetrahedron Letters, 2010 , vol. 51, # 42 p. 5624 - 5627
反应条件
1.1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride / N-methyl-pyrrolidine / 7 h / 100 °C / Inert atmosphere
2.1: n-butyllithium; tri-isopropoxy-borane / tetrahydrofuran; hexane / 3.08 h / -78 °C
2.2: -78 - 20 °C
View Scheme
参考文献
Bueno, Jose M.; Manzano, Pilar; Garcia, Maria C.; Chicharro, Jesus; Puente, Margarita; Lorenzo, Milagros; Garcia, Adolfo; Ferrer, Santiago; Gomez, Ruben M.; Fraile, Maria T.; Lavandera, Jose L.; Fiandor, Jose M.; Vidal, Jaume; Herreros, Esperanza; Gargallo-Viola, Domingo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5214 - 5218
