4-甲基-3-硝基苯甲酰氯合成路线 （共 16 条）
参考文献
Li, Shuxin; Yao, Zhenglin; Zhao, Yanjin; Chen, Wei; Wang, Huijia; Kuang, Xianzhao; Zhan, Wenhu; Yao, Shan; Yu, Shanyou; Hu, Wenxiang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5279 - 5282
反应条件
1: sulfuric acid / Hydrolysis 2: phosphorus pentachloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 47, p. 1394
反应条件
1: durch Nitrierung 2: sulfuric acid / Hydrolysis 3: phosphorus pentachloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 47, p. 1394
反应条件
1: durch Nitrierung 2: phosphorus pentachloride View Scheme
参考文献
Journal of the Chemical Society, , vol. 127, p. 2649
反应条件
sodium tetrahydroborate; water in 1,4-dioxane Cooling with iceReflux;
参考文献
Bayer CorpScience AG
Patent: US2010/179194 A1, 2010 ;
Location in patent: Page/Page column 25 ;
反应条件
triethylamine in dichloromethane T=0 - 5°C; 1.75 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/149031 A1, 2007 ;
Location in patent: Page/Page column 51 ;
WO 2007/149031 A1
反应条件
1.1: chloroform; N,N-dimethyl-formamide / 5 h / 10 - 20 °C 2.1: tin(ll) chloride / methanol / 10 °C / |Reflux 2.2: 2 h / 10 - 15 °C 3.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3 3.2: 2 h / 20 °C 4.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 8 p. 4599 - 4602
反应条件
1: triethylamine / dichloromethane / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C View Scheme
参考文献
Brown, Dearg S.; Cumming, John G.; Bethel, Paul; Finlayson, Jonathan; Gerhardt, Stefan; Nash, Ian; Pauptit, Richard A.; Pike, Kurt G.; Reid, Alan; Snelson, Wendy; Swallow, Steve; Thompson, Caroline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3879 - 3883
反应条件
1: 88.1 percent / toluene; H2O / pH 4 2: 95.6 percent / H2 / Pd/C / H2O 3: 68.8 percent / toluene; H2O / pH 4 4: 85.3 percent / H2 / Pd/C / H2O 5: toluene; H2O / pH 4 View Scheme
参考文献
Nickel; Haack; Widjaja; Ardanuy; Gurgel; Duewel; Loewe; Raether
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 8 p. 1153 - 1157
反应条件
1: in hexane; dichloromethane T=20°C; 2 h; 2: With hydrogen bromide; acetic acid in hexane; dichloromethane T=0°C;
参考文献
PAMLICO PHARMACEUTICAL INC.; ATKINSON, Robert N.; OMMEN, Andy J.; VEAL, James M.; HUANG, Kenneth H.; SMITH, Emilie, D.
Patent: WO2012/88411 A1, 2012 ;
Location in patent: Page/Page column 39 ;
