1: iron, acetic acid / 1 h / Heating 2: acetic acid 3: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 4: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 5: 80 percent / 2 h / Heating 6: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme

Multi-step reaction with 3 steps 1: iron, acetic acid / 1 h / Heating2: acetic acid3: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature  

Multi-step reaction with 4 steps 1: iron, acetic acid / 1 h / Heating2: acetic acid3: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature4: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating  

Multi-step reaction with 5 steps 1: iron, acetic acid / 1 h / Heating2: acetic acid3: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature4: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating5: 80 percent / 2 h / Heating