6,7-二氟-1-(4-氟苯基)-4-氧代-1,4-二氢喹啉-3-羧酸合成路线 （共 7 条）
反应条件
hydrogenchloride; acetic acid
参考文献
Pfizer Inc.
Patent: US5037834 A1, 1991 ;
反应条件
1: 1.) Ac2O / 2.) Et2O 2: NaH / tetrahydrofuran 3: 6 M HCl View Scheme
参考文献
Schmidt, Burkhard; Schumacher-Buffel, Ramona; Thiede, Brigitte; Schaeffer, Andreas
Monatshefte fur Chemie, 2009 , vol. 140, # 10 p. 1221 - 1227
反应条件
1: 1.) (COCl)2, 2.) C3H7MgCl / 1.) CH2Cl2, DMF, 2.) THF 2: 1.) Ac2O / 2.) Et2O 3: NaH / tetrahydrofuran 4: 6 M HCl View Scheme
参考文献
Renau, Thomas E.; Sanchez, Joseph P.; Shapiro, Martin A.; Dever, Julie A.; Gracheck, Stephen J.; Domagala, John M.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2974 - 2977
反应条件
1: NaH / tetrahydrofuran 2: 6 M HCl View Scheme
参考文献
Renau, Thomas E.; Sanchez, Joseph P.; Shapiro, Martin A.; Dever, Julie A.; Gracheck, Stephen J.; Domagala, John M.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2974 - 2977
反应条件
1: dichloromethane / Inert atmosphere 2: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere; Heating 3: hydrogenchloride; water; acetic acid / Reflux View Scheme
参考文献
Schmidt, Burkhard; Schumacher-Buffel, Ramona; Thiede, Brigitte; Schaeffer, Andreas
Monatshefte fur Chemie, 2009 , vol. 140, # 10 p. 1221 - 1227
反应条件
triethylamine in acetonitrile Inert atmosphereReflux;
参考文献
Schmidt, Burkhard; Schumacher-Buffel, Ramona; Thiede, Brigitte; Schaeffer, Andreas
Monatshefte fur Chemie, 2009 , vol. 140, # 10 p. 1221 - 1227
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2974 - 2977
