1: 2-(4-nitrophenyl)acetic acid With hydrogen; palladium 10 on activated carbon in water T=44 - 58°C; Inert atmosphereAutoclaveIndustry scale; 2: ethanol With hydrogenchloride in water RefluxIndustry scale;
1: phosphorus pentoxide on alumina / 6 h / |Reflux 2: palladium 10 on activated carbon; hydrogenchloride; hydrogen / water; methanol / 24 h / 2585.81 Torr View Scheme
参考文献
Mosberg, Henry I.; Yeomans, Larisa; Harland, Aubrie A.; Bender, Aaron M.; Sobczyk-Kojiro, Katarzyna; Anand, Jessica P.; Clark, Mary J.; Jutkiewicz, Emily M.; Traynor, John R.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 2139 - 2149