反应条件
1.1: diisopropylamine; n-butyllithium; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; water / 1.67 h / -78 °C / |Inert atmosphere
1.2: 1.5 h / -78 °C / |Inert atmosphere
2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 2 h / 60 °C
3.1: triethylamine; copper(l) chloride / N,N-dimethyl acetamide / 3 h / 20 - 130 °C
4.1: tetrahydrofuran / -50 - -40 °C / |Inert atmosphere
5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 2 h / -30 - -25 °C / |Inert atmosphere
View Scheme
参考文献
Li, Hao; Xia, Zhiqiang; Chen, Shoujun; Koya, Keizo; Ono, Mitsunori; Sun, Lijun
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 246 - 250
