1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 80.9 percent / tetrahydrofuran / 6 h
2.1: 77.7 percent / PDC; molecular sieves 4 A / CH2Cl2 / 24 h
View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
1: 1-bromo-4-methoxy-benzene With (nBu)3MgLi in tetrahydrofuran
T=0°C; 0.0833333 h;
2: 1-trifluoromethyl-4-bromobenzene With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran
T=0°C; Kumada-Corriu cross-coupling; Further stages.;
参考文献
Lau, Stephen Y. W.; Hughes, Greg; O'Shea, Paul D.; Davies, Ian W.
Organic Letters, 2007 , vol. 9, # 11 p. 2239 - 2242
