2-茴香胺亚甲基丙二酸二乙酯合成路线 （共 5 条）
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 66 ;
US 20070049603 A1
反应条件
1.1: diphenylether / 2 h / Reflux; Inert atmosphere 2.1: sodium hydroxide / water / 3 h / Reflux 3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere 3.2: 4 h / 20 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere View Scheme
参考文献
Pasquini, Serena; De Rosa, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, Francesca; Luongo, Livio; De Chiaro, Maria; Maione, Sabatino; Dragoni, Stefania; Frosini, Maria; Ligresti, Alessia; Di Marzo, Vincenzo; Corelli, Federico
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5444 - 5453
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Pasquini, Serena; De Rosa, Maria; Pedani, Valentina; Mugnaini, Claudia; Guida, Francesca; Luongo, Livio; De Chiaro, Maria; Maione, Sabatino; Dragoni, Stefania; Frosini, Maria; Ligresti, Alessia; Di Marzo, Vincenzo; Corelli, Federico
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5444 - 5453
反应条件
in dowtherm A T=250°C;
参考文献
Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark
Patent: US2007/49603 A1, 2007 ;
Location in patent: Page/Page column 66 ;
US 20070049603 A1
反应条件
Eaton's reagent
T=90 - 100°C; Inert atmosphere;
参考文献
Mistry, Shailesh N.; Valant, Celine; Sexton, Patrick M.; Capuano, Ben; Christopoulos, Arthur; Scammells, Peter J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5151 - 5172
