1: tetrazole / acetonitrile; tetrahydrofuran / 3 h / Ambient temperature 2: t-butyl hydroperoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h 3: trimethylamine / toluene / 12 h / Ambient temperature 4: tetrabutylammonium fluoride / tetrahydrofuran / 48 h / Ambient temperature 5: sodium deoxycholate / 37 °C / phospholipaze in HEPES buffer (pH 8.0) View Scheme

1: tetrazole / acetonitrile; tetrahydrofuran / 3 h / Ambient temperature 2: t-butyl hydroperoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h 3: trimethylamine / toluene / 12 h / Ambient temperature 4: tetrabutylammonium fluoride / tetrahydrofuran / 48 h / Ambient temperature 5: sodium deoxycholate / 37 °C / phospholipaze in HEPES buffer (pH 8.0) View Scheme

Multi-step reaction with 3 steps 1: 1.) tetrazole, 2.) t-BuOOH / 1.) acetonitrile-THF, 2.) toluene2: Me3N / toluene3: Bu4N(1+)*F(1-) / tetrahydrofuran  

Multi-step reaction with 3 steps 1: 1.) tetrazole, 2.) S8 / 1.) acetonitrile-THF, 2.) toluene2: Me3N / toluene3: Bu4N(1+)*F(1-) / tetrahydrofuran  

Multi-step reaction with 2 steps 1: tetrazole / acetonitrile; tetrahydrofuran / 3 h / Ambient temperature2: t-butyl hydroperoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h  

Multi-step reaction with 2 steps 1: 1.) tetrazole, 2.) t-BuOOH / 1.) acetonitrile-THF, 2.) toluene2: Me3N / toluene