2-羟基-4-三氟甲基嘧啶合成路线 （共 4 条）
反应条件
hydrogenchloride in ethanol T=22°C; 48 h;
参考文献
Gerus, I. I.; Vdovenko, S. I.; Gorbunova, M. G.; Kukhar', V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 4 p. 398 - 406
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , # 4 p. 502 - 511
反应条件
N,N-dimethyl-aniline; phosphorus oxytribromide in toluene T=20 - 100°C; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0604; 0605; 0606 ;
反应条件
1: phosphorus oxytribromide; N,N-dimethyl-aniline / toluene / 20 - 100 °C / |Inert atmosphere 2: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; triethylamine / acetonitrile / 20 - 100 °C / |Inert atmosphere 3: diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / -40 °C / |Inert atmosphere View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
in diethyl ether T=22°C; 2 h;
参考文献
Gerus, I. I.; Vdovenko, S. I.; Gorbunova, M. G.; Kukhar', V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 4 p. 398 - 406
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , # 4 p. 502 - 511
