6-氯-1-甲基-1H-苯并咪唑合成路线 （共 4 条）
反应条件
hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal in ethyl acetate T=20°C; P=2585.74 Torr; 6 h;
参考文献
Hornberger, Keith R.; Adjabeng, George M.; Dickson, Hamilton D.; Davis-Ward, Ronda G.
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5359 - 5361
反应条件
copper(l) iodide; copper(l) chloride in 1-methyl-pyrrolidin-2-one T=200°C; 1.5 h; Microwave irradiationInert atmosphere;
参考文献
NOVARTIS AG; CHAMOIN, Sylvie; HU, Qi-Ying; PAPILLON, Julien
Patent: WO2010/130796 A1, 2010 ;
Location in patent: Page/Page column 99-100 ;
反应条件
1: 6-chloro-1H-benzo[d]imidazole With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: methyl iodide in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Nakao, Yoshiaki; Kanyiva, Kyalo Stephen; Oda, Shinichi; Hiyama, Tamejiro
Journal of the American Chemical Society, 2006 , vol. 128, # 25 p. 8146 - 8147
参考文献
Davies et al.
Journal of Pharmacy and Pharmacology, 1951 , vol. 3, p. 420,424
