6-甲基-6-庚烯-2-酮合成路线 （共 52 条）
反应条件
1: 1.) SeO2, salicylic acid, tert-butyl hydroperoxide, 2.) dimethyl sulphide / 1.) CH2Cl2, RT, 1 h, 2.) CH2Cl2, RT, 1 h
2: 57 percent / pyridine / CH2Cl2 / 0 °C
3: formic acid, Et3N, <Ru(1,5-cyclooctadiene)(1,3,5-cyclooctatriene) / dioxane / 27 h / Heating
View Scheme
参考文献
Maruyama, Yooichiroh; Sezaki, Takao; Tekawa, Masafumi; Sakamoto, Toshiaki; Shimizu, Isao; Yamamoto, Akio
Journal of Organometallic Chemistry, 1994 , vol. 473, # 1-2 p. 257 - 264
反应条件
1: 57 percent / pyridine / CH2Cl2 / 0 °C
2: formic acid, Et3N, <Ru(1,5-cyclooctadiene)(1,3,5-cyclooctatriene) / dioxane / 27 h / Heating
View Scheme
参考文献
Maruyama, Yooichiroh; Sezaki, Takao; Tekawa, Masafumi; Sakamoto, Toshiaki; Shimizu, Isao; Yamamoto, Akio
Journal of Organometallic Chemistry, 1994 , vol. 473, # 1-2 p. 257 - 264
反应条件
1: 1) n-BuLi, HMPA / 1) THF, hexane, 30 min, -78 deg C, 2) THF, to r.t., overnight
2: 86 percent / sodium periodate / methanol / 25 °C / other solvent: phosphate buffer (pH 7)
View Scheme
参考文献
Trehan, I. R.; Kad, G. L.; Gupta, Sangita
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1243 - 1244
反应条件
1: 40 percent / NaI / acetone / 10 h / Heating
2: 1.) LDA / 1.) THF, 0 deg C, 1 h; 2.) r.t., 2 h
3: 70 percent / 50percent aq.NaOH / 2 h / Heating
View Scheme
参考文献
Ishihara, Kazuaki; Mori, Atsunori; Yamamoto, Hisashi
Tetrahedron, 1990 , vol. 46, # 13/14 p. 4595 - 4612
反应条件
1: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
2: 97 percent / pyridine
3: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: pyridine
2: NaI / acetone
3: (i) Mg, Et2O, (ii) /BRN= 385737/
View Scheme
参考文献
Ansell,M.F.; Thomas,D.A.
Journal of the Chemical Society, 1961 , p. 539 - 542
反应条件
1: NaI / acetone
2: (i) Mg, Et2O, (ii) /BRN= 385737/
View Scheme
参考文献
Ansell,M.F.; Thomas,D.A.
Journal of the Chemical Society, 1961 , p. 539 - 542
反应条件
und anschliessenden Hydrolyse;
参考文献
Albisetti et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 2637,2641
反应条件
ammonium formate; Pd(OAc)2-P(n-Bu)3 in 1,4-dioxane
2 h; Heating;
参考文献
Tsuji, Jiro; Shimizu, Isao; Minami, Ichiro
Chemistry Letters, 1984 , p. 1017 - 1020
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide
1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h; Yield given. Multistep reaction;
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
