3,3-双(溴甲基)-1-甲苯磺酰氮杂丁烷合成路线 （共 3 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0 - 20°C;
参考文献
JANSSEN PHARMACEUTICA NV; BREITENBUCHER, Guy, J.; KEITH, John, M.; JONES, William, M.
Patent: WO2010/141817 A1, 2010 ;
Location in patent: Page/Page column 30 ;
WO 2010/141817 A1
反应条件
1: hydrogen bromide / diethyl ether; acetic acid / 1.33 h / 0 - 20 °C 2: carbon tetrabromide; triphenylphosphine / dichloromethane / 6 h / 0 - 20 °C View Scheme
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 72 h; Reflux;
参考文献
Burkhard, Johannes; Carreira, Erick M.
Organic Letters, 2008 , vol. 10, # 16 p. 3525 - 3526
