2’-氨基-2’-脱氧腺苷合成路线 （共 13 条）
反应条件
1: 57.9 percent / pyridine / 16 h / 45 °C 2: 48 percent / POCl3, diethylaniline / 0.08 h / Heating 3: 1.) ammonia, 2.) NaOMe / 1.) methanol, 120 deg C, 3 h, autoclave, 2.) methanol, reflux, 8 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 11 p. 3191 - 3195
反应条件
1: 48 percent / POCl3, diethylaniline / 0.08 h / Heating 2: 1.) ammonia, 2.) NaOMe / 1.) methanol, 120 deg C, 3 h, autoclave, 2.) methanol, reflux, 8 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 11 p. 3191 - 3195
反应条件
water; adenosine deaminase T=20°C;
参考文献
Bressi; Verlinde; Aronov; Shaw; Shin; Nguyen; Suresh; Buckner; van Voorhis; Kuntz; Hol; Gelb
Journal of Medicinal Chemistry, 2001 , vol. 44, # 13 p. 2080 - 2093
