sodium methylate in tetrahydrofuran; methanol T=-2 - 2°C; 4.25 h; Product distribution / selectivity;

sodium methylate in tetrahydrofuran; methanol T=-2 - 2°C; 5.25 h; Product distribution / selectivity;

1: sodium iodide / acetone / 5 h / -5 - 0 °C / Darkness; Inert atmosphere 2: ethyl acetate / -5 °C / Inert atmosphere 3: phenol / 4.5 h / 50 °C 4: penicillin G acylase / water / 37 °C / pH 8 - 8.5 / aq. acetate buffer; Enzymatic reaction 5: tetrahydrofuran; water / 6.5 h / 25 °C / pH 6.8 - 7.2 6: sulfuric acid / water / 5 °C / pH 1 - 2 View Scheme

1: sodium iodide / acetone / 5 h / -5 - 0 °C / Darkness; Inert atmosphere 2: ethyl acetate / -5 °C / Inert atmosphere 3: phenol / 4.5 h / 50 °C 4: penicillin G acylase / water / 37 °C / pH 8 - 8.5 / aq. acetate buffer; Enzymatic reaction 5: tetrahydrofuran; water / 6.5 h / 25 °C / pH 6.8 - 7.2 View Scheme

1: NaI / acetone / 2 h / Ambient temperature 2: NaHCO3 / CH2Cl2; H2O / 17 h / Ambient temperature 3: 1) POCl3, pyridine, 2) MeOH / 1) CH2Cl2, 0-5 deg C, 2 h, 2) 0-5 deg C, 1 h 4: 632 mg / POCl3, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 5: 95 mg / CF3CO2H, anisole / 1 h / 0 °C View Scheme

暂无反应条件数据

1: NaI / acetone / 2 h / Ambient temperature 2: NaHCO3 / CH2Cl2; H2O / 17 h / Ambient temperature 3: 1) POCl3, pyridine, 2) MeOH / 1) CH2Cl2, 0-5 deg C, 2 h, 2) 0-5 deg C, 1 h 4: 632 mg / POCl3, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 5: 95 mg / CF3CO2H, anisole / 1 h / 0 °C 6: 25 mg / dimethylformamide / 1 h / -20 °C View Scheme

暂无反应条件数据