(9CI)-吡啶并[2,3-e]吡咯并[1,2-a]吡嗪-6(4H)-酮合成路线 （共 17 条）
反应条件
in 1,2-dichloro-benzene
T=180°C; 0.166667 h;
参考文献
Lancelot; Laduree; Robba
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3122 - 3128
反应条件
in 1,2-dichloro-benzene
T=180°C; 1 h;
参考文献
Lancelot; Laduree; Robba
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3122 - 3128
反应条件
in toluene
Acylation; cyclization; 1.5 h; Heating;
参考文献
Campiani, Giuseppe; Morelli, Elena; Gemma, Sandra; Nacci, Vito; Butini, Stefania; Hamon, Michel; Novellino, Ettore; Greco, Giovanni; Cagnotto, Alfredo; Goegan, Mara; Cervo, Luigi; Valle, Fabio Dalla; Fracasso, Claudia; Caccia, Silvio; Mennini, Tiziana
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4362 - 4379
反应条件
1: 86 percent / H2 / Pd/C / 0.5 h / 2585.7 Torr
2: 48 percent / acetic acid / 1 h / Heating
3: 63 percent / ammonia / methanol / 23 h / 260 °C
4: 1 h / Heating
View Scheme
参考文献
Peet, Norton P.; Sunder, Shyam
Heterocycles, 1986 , vol. 24, # 11 p. 3213 - 3221
反应条件
1: 73 percent / potassium fluoride / dimethylformamide / 6 h / 150 °C
2: 86 percent / H2 / Pd/C / 0.5 h / 2585.7 Torr
3: 48 percent / acetic acid / 1 h / Heating
4: 63 percent / ammonia / methanol / 23 h / 260 °C
5: 1 h / Heating
View Scheme
参考文献
Peet, Norton P.; Sunder, Shyam
Heterocycles, 1986 , vol. 24, # 11 p. 3213 - 3221
反应条件
1: 78 percent / bis(trimethylsilyl)acetamide / CH2Cl2 / 25 h / 20 °C
2: 94 percent / tin(II) chloride dihydrate / ethanol / 30 h / Heating
3: 42 percent / gl. AcOH / 1 h / Heating
4: 72 percent / toluene / 1.5 h / Heating
View Scheme
参考文献
Campiani, Giuseppe; Morelli, Elena; Gemma, Sandra; Nacci, Vito; Butini, Stefania; Hamon, Michel; Novellino, Ettore; Greco, Giovanni; Cagnotto, Alfredo; Goegan, Mara; Cervo, Luigi; Valle, Fabio Dalla; Fracasso, Claudia; Caccia, Silvio; Mennini, Tiziana
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4362 - 4379
反应条件
1: 42 percent / gl. AcOH / 1 h / Heating
2: 72 percent / toluene / 1.5 h / Heating
View Scheme
参考文献
Campiani, Giuseppe; Morelli, Elena; Gemma, Sandra; Nacci, Vito; Butini, Stefania; Hamon, Michel; Novellino, Ettore; Greco, Giovanni; Cagnotto, Alfredo; Goegan, Mara; Cervo, Luigi; Valle, Fabio Dalla; Fracasso, Claudia; Caccia, Silvio; Mennini, Tiziana
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4362 - 4379
反应条件
T=90°C; 1 h; Heating;
参考文献
Lancelot; Laduree; Robba
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3122 - 3128
反应条件
in toluene
1.5 h; Heating;
参考文献
Lancelot; Laduree; Robba
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3122 - 3128
反应条件
in toluene
1 h; Heating;
参考文献
Lancelot; Laduree; Robba
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3122 - 3128
