(alphaR)-alpha-(苯甲酰基氨基)-苯乙酸合成路线 （共 14 条）
反应条件
ozone in methanol T=-78°C; 0.25 h;
参考文献
Demir, Ayhan S.; Sesenoglu, Oezge; Uelkue, Dincer; Arici, Cengiz
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 91 - 105
反应条件
in tetrahydrofuran T=20°C; 168000 h;
参考文献
Cichelli, Julie; Zharov, Ilya
Journal of Materials Chemistry, 2007 , vol. 17, # 19 p. 1870 - 1875
反应条件
in water T=25°C; 20 h; biosynthesis by lipase from Aspergillus niger (AP); phosphate buffer, pH: 7.6; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Gu, Rui-Lin; Lee, Ik-Soo; Sih, Charles J.
Tetrahedron Letters, 1992 , vol. 33, # 15 p. 1953 - 1956
反应条件
1: MgSO4 / CH2Cl2 / 2 h / 0 °C 2: imidazole / CH2Cl2 / 3 h 3: 1.) BuLi / 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 8 h; 0 to 20 deg C 4: TBAF, H2O / tetrahydrofuran 5: 1.) H5IO6, MeNH2, 2.) HCl, H2O / 1.) MeOH, H2O 6: Et3N / CH2Cl2 / 3 h 7: 75 percent / NaIO4, RuO2*H2O, H2O / acetonitrile; CCl4 / 2 h View Scheme
参考文献
Alvaro, Giuseppe; Martelli, Gianluca; Savoia, Diego; Zoffoli, Andrea
Synthesis, 1998 , # 12 p. 1773 - 1777
反应条件
1: imidazole / CH2Cl2 / 3 h 2: 1.) BuLi / 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 8 h; 0 to 20 deg C 3: TBAF, H2O / tetrahydrofuran 4: 1.) H5IO6, MeNH2, 2.) HCl, H2O / 1.) MeOH, H2O 5: Et3N / CH2Cl2 / 3 h 6: 75 percent / NaIO4, RuO2*H2O, H2O / acetonitrile; CCl4 / 2 h View Scheme
参考文献
Alvaro, Giuseppe; Martelli, Gianluca; Savoia, Diego; Zoffoli, Andrea
Synthesis, 1998 , # 12 p. 1773 - 1777
反应条件
1: 1.) BuLi / 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 8 h; 0 to 20 deg C 2: TBAF, H2O / tetrahydrofuran 3: 1.) H5IO6, MeNH2, 2.) HCl, H2O / 1.) MeOH, H2O 4: Et3N / CH2Cl2 / 3 h 5: 75 percent / NaIO4, RuO2*H2O, H2O / acetonitrile; CCl4 / 2 h View Scheme
参考文献
Alvaro, Giuseppe; Martelli, Gianluca; Savoia, Diego; Zoffoli, Andrea
Synthesis, 1998 , # 12 p. 1773 - 1777
反应条件
1: Et3N / CH2Cl2 / 3 h 2: 75 percent / NaIO4, RuO2*H2O, H2O / acetonitrile; CCl4 / 2 h View Scheme
参考文献
Alvaro, Giuseppe; Martelli, Gianluca; Savoia, Diego; Zoffoli, Andrea
Synthesis, 1998 , # 12 p. 1773 - 1777
反应条件
1.1: 69 percent / NH2OH*HCl; AcONa / ethanol / 12 h / Heating 2.1: NaH / dimethylformamide / 1 h / 0 °C 2.2: 91 percent / dimethylformamide / 2 h / 20 °C 3.1: BH3; (R,S)-norephedrine / tetrahydrofuran / 48 h / 30 °C 3.2: pyridine / 2 h / 20 °C 4.1: 89 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Demir, Ayhan S.; Sesenoglu, Oezge; Uelkue, Dincer; Arici, Cengiz
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 91 - 105
反应条件
1.1: NaH / dimethylformamide / 1 h / 0 °C 1.2: 91 percent / dimethylformamide / 2 h / 20 °C 2.1: BH3; (R,S)-norephedrine / tetrahydrofuran / 48 h / 30 °C 2.2: pyridine / 2 h / 20 °C 3.1: 89 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Demir, Ayhan S.; Sesenoglu, Oezge; Uelkue, Dincer; Arici, Cengiz
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 91 - 105
反应条件
1.1: BH3; (R,S)-norephedrine / tetrahydrofuran / 48 h / 30 °C 1.2: pyridine / 2 h / 20 °C 2.1: 89 percent / O3 / methanol / 0.25 h / -78 °C View Scheme
参考文献
Demir, Ayhan S.; Sesenoglu, Oezge; Uelkue, Dincer; Arici, Cengiz
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 91 - 105
