4-溴-2,6-二氟苯酚合成路线 （共 10 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0 - 20°C; 20 h;
参考文献
Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd.
Patent: US2011/118257 A1, 2011 ;
Location in patent: Page/Page column 100 ;
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With fluorodimethoxyborane*Et2O in tetrahydrofuran T=-78 - 0°C; 3: With water; dihydrogen peroxide; sodium hydroxide in tetrahydrofuran T=0 - 20°C;
参考文献
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE; UNIVERSITE DE STRASBOURG; CHOPPIN, Sabine; COLOBERT, Francoise; HANQUET, Gilles; LEROUX, Frederic; MAHMOUDI, Nassira; MAZIER, Dominique
Patent: WO2010/40730 A1, 2010 ;
Location in patent: Page/Page column 39 ;
反应条件
hydrogen bromide; bromine in carbon disulfide
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h; Title compound not separated from byproducts;
参考文献
Journal of Fluorine Chemistry, , vol. 102, # 1-2 p. 169 - 173
反应条件
1: nBuLi / tetrahydrofuran / -78 - 20 °C 2: H+ / 20 °C 3: H2O2 / diethyl ether / 20 °C 4: 71.7 percent / Br / acetic acid / 4 h / 0 - 20 °C View Scheme
参考文献
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, , vol. 373, p. 1 - 15
反应条件
1: H2O2 / diethyl ether / 20 °C 2: 71.7 percent / Br / acetic acid / 4 h / 0 - 20 °C View Scheme
参考文献
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, , vol. 373, p. 1 - 15
反应条件
in N-methyl-acetamide; ethyl acetate
参考文献
Sterling Winthrop Inc.
Patent: US5464848 A1, 1995 ;
US 5464848 A
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium acetate in 1,4-dioxane T=100°C; 10.5 h; Inert atmosphere;
参考文献
Mita, Yusuke; Noguchi-Yachide, Tomomi; Ishikawa, Minoru; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 3 p. 608 - 617
反应条件
potassium carbonate in acetone T=0 - 20°C; 22 h;
参考文献
US2011/118257 A1, ;
Page/Page column 100 ;
反应条件
in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP276558 A2, 1988 ;
