4-溴-2,6-二氟苯甲醚合成路线 （共 4 条）
反应条件
potassium carbonate in acetone T=0 - 20°C; 22 h;
参考文献
US2011/118257 A1, ;
Page/Page column 100 ;
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h; Title compound not separated from byproducts;
参考文献
Journal of Fluorine Chemistry, , vol. 102, # 1-2 p. 169 - 173
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 20 h / 0 - 20 °C 2: potassium carbonate / acetone / 22 h / 0 - 20 °C View Scheme
反应条件
in N,N-dimethyl-formamide T=120°C; 48 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/135316 A1, 2006 ;
Location in patent: Page/Page column 55 ;
WO 2006/135316 A1
