1: 53 percent / NaOH, TEBA / tetrahydrofuran / Ambient temperature 2: 36 percent / silver(II) dipicolinate / benzene; H2O / 1.5 h / Ambient temperature View Scheme

With  n-butyllithium in  water; N,N-dimethyl-formamide Show Experimental Procedure  

With  n-butyllithium  1.) hexane, THF, 3 h, - 5 deg C, 2.) 1 h;  Yield given. Multistep reaction;