1,3-二甲基-2-(2-噻吩)咪唑烷合成路线 （共 7 条）
反应条件
in toluene T=0°C; 3 h; Heating / reflux;
参考文献
METABASIS THERAPEUTICS, INC.
Patent: WO2009/23718 A2, 2009 ;
Location in patent: Page/Page column 143-145 ;
WO 2009/023718 A2
反应条件
Yield given. Multistep reaction;
参考文献
Renouard, Thierry; Graetzel, Michael
Tetrahedron, 2001 , vol. 57, # 38 p. 8145 - 8150
反应条件
sulfuric acid T=20°C; 2 h;
参考文献
Carpenter, Andrew J,; Chadwick, Derek J.
Tetrahedron, 1985 , vol. 41, # 18 p. 3803 - 3812
反应条件
Yield given. Multistep reaction;
参考文献
Carpenter, Andrew J,; Chadwick, Derek J.
Tetrahedron, 1985 , vol. 41, # 18 p. 3803 - 3812
反应条件
Yield given. Multistep reaction;
参考文献
Carpenter, Andrew J,; Chadwick, Derek J.
Tetrahedron, 1985 , vol. 41, # 18 p. 3803 - 3812
反应条件
1: BuLi / tetrahydrofuran
2: 53 percent / Na2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Renouard, Thierry; Graetzel, Michael
Tetrahedron, 2001 , vol. 57, # 38 p. 8145 - 8150
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine; sulfuric acid
Yield given. Multistep reaction;
参考文献
Varache-Lembege; Nuhrich; Zemb; Devaux; Vacher; Dufy
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 7-8 p. 547 - 556
