2-(1-金刚烷基)-4-溴苯甲醚合成路线 （共 15 条）
反应条件
1: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane 2: 81 percent / 2 N NaOH / methanol / 8 h / Heating View Scheme
参考文献
Milanese, Alberto; Gorincioi, Elena; Rajabi, Mehdi; Vistoli, Giulio; Santaniello, Enzo
Bioorganic Chemistry, 2011 , vol. 39, # 4 p. 151 - 158
反应条件
1: 2-(1-adamantyl)-4-bromo-1-methoxybenzene With iodine; magnesium in tetrahydrofuran T=40°C; 1 h; Inert atmosphere; 2: 6-bromo-naphthalene-2-carboxylic acid methyl ester With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride in tetrahydrofuran T=55°C; Negishi Coupling; 0.75 h;
参考文献
Liu, Zhichang; Xiang, Jiannan
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 285 - 288
反应条件
1: 2-(1-adamantyl)-4-bromo-1-methoxybenzene With magnesium; ethylene dibromide in tetrahydrofuran T=45 - 55°C; 1.5 h; 2: With zinc(II) chloride in tetrahydrofuran T=20 - 25°C; 1 h; 3: 6-bromo-naphthalene-2-carboxylic acid methyl ester With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran T=20°C; 2 h;
参考文献
Puig Serrano, Jordi
Patent: US2009/131713 A1, 2009 ;
Location in patent: Page/Page column 3; 5 ;
反应条件
1: magnesium / tetrahydrofuran / 1 h / 40 °C 2: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme
参考文献
Milanese, Alberto; Gorincioi, Elena; Rajabi, Mehdi; Vistoli, Giulio; Santaniello, Enzo
Bioorganic Chemistry, 2011 , vol. 39, # 4 p. 151 - 158
反应条件
1: 2-(1-adamantyl)-4-bromo-1-methoxybenzene With magnesium; ethylene dibromide in tetrahydrofuran
RefluxInert atmosphere;
2: boric acid trimethyl ester in tetrahydrofuran
T=-50 - -40°C; 0.5 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran
参考文献
Kalvinsh, Ivars; Chernobrovijs, Aleksandrs; Tribulovich, Vyacheslav; Labeish, Vladimir
Patent: US2010/113816 A1, 2010 ;
Location in patent: Page/Page column 3 ;
