2-[2-(2-氨基-9h-嘌呤-9-基)乙基]-1,3-丙二醇合成路线 （共 31 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol; water; ethyl acetate T=55°C; P=6000.6 Torr; 4 h;
参考文献
US2006/264629 A1, ;
Page/Page column 4; 5 ;
反应条件
sodium formate; palladium on activated carbon in methanol T=60°C; 7.5 h;
参考文献
US6342603 B1, ;
Example II-6 ;
反应条件
ammonium formate; palladium on charcoal in methanol; methyl acetate T=40°C; 6.16667 h; Product distribution / selectivity;
参考文献
WO2004/99208 A1, ;
Page 6-7 ;
反应条件
hydrogenchloride; palladium in ethanol; water; cyclohexene
反应条件
1: 78 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating 2: 96 percent / ammonia / methanol / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1738 - 1743
反应条件
ammonia in methanol 18 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1738 - 1743
反应条件
water; ammonium formate; palladium on charcoal in methanol; i-BuOAc T=50°C; 5 h; Product distribution / selectivity;
参考文献
WO2004/99208 A1, ;
Page 9-10 ;
反应条件
1: With hydrogenchloride in ethanol T=23°C; 0.0833333 - 0.166667 h; 2: With orthoformic acid triethyl ester in ethanol T=45 - 50°C; 3 h; Product distribution / selectivity;
参考文献
WO2008/72074 A1, ;
Page/Page column 11-12 ;
反应条件
1: 100 percent / sodium borohydride, MeOH / 2-methyl-propan-2-ol / 0.5 h / Heating 2: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature 3: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C 4: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 5: cyclohexene / 10percent Pd/C / ethanol / Heating 6: aq. HCl / ethanol; cyclohexene; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
反应条件
1: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature 2: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C 3: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 4: cyclohexene / 10percent Pd/C / ethanol / Heating 5: aq. HCl / ethanol; cyclohexene; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
