2-[2-(2-氨基-9h-嘌呤-9-基)乙基]-1,3-丙二醇合成路线 （共 31 条）
反应条件
1: aq. NaOH / 0.5 h / Heating 2: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 3: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 4: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 5: 99 percent / aq. MeNH2 / 0.25 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
反应条件
1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 2: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 3: 99 percent / aq. MeNH2 / 0.25 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
反应条件
1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 2: 99 percent / aq. MeNH2 / 0.25 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
反应条件
hydrogenchloride in methanol; ethanol; cyclohexene 0.5 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
反应条件
methanol; sodium tetrahydroborate in dichloromethane T=20°C; 2.5 h;
参考文献
Heterocycles, , vol. 75, # 11 p. 2803 - 2808
反应条件
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere 2: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 3: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 4: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 75, # 11 p. 2803 - 2808
反应条件
1: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 °C 2: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 3: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 75, # 11 p. 2803 - 2808
反应条件
4-(N,N-dimethlyamino)pyridine in propionic acid anhydride; N,N-dimethyl-formamide
参考文献
BEECHAM GROUP PLC
Patent: EP182024 B1, 1991 ;
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide 0.166667 h;
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Boyd, Malcolm R.; Sutton, David; Hodge, R. Anthony Vere
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1738 - 1743
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 3 h;
参考文献
Synthesis, , # 12 p. 2026 - 2034
