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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
泛昔洛韦
合成路线
（共 53 条）
225111-66-0
→
反应条件
104227-87-4
泛昔洛韦
反应条件
nickel in ethanol; water 1 h; Heating;
参考文献
Tetrahedron, , vol. 55, # 16 p. 5239 - 5252
73-40-5
鸟嘌呤
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C 2.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 3.2: NH4OH / 1 h / Heating 4.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 5.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 6.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 7.1: aq. NaOH / 0.5 h / Heating 8.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 9.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 10.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 11.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 12.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
172529-94-1
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1: NEt3; DMAP / CH2Cl2 / 2 h / Heating 2: 81 percent / hydrogen; NEt3 / Pd/C / ethyl acetate / 4 h / 50 °C / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 9 p. 1781 - 1784
127047-77-2
2-(乙酰氧基甲基)-4-碘乙酸丁酯
+
452-06-2
2-氨基嘌呤
→
反应条件
131266-15-4
+
104227-87-4
泛昔洛韦
反应条件
potassium carbonate in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 46, # 19 p. 6903 - 6914
17495-12-4
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 2: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 3: HCOONH4 / Pd/C / methanol / 4 h / Heating 4: aq. NaOH / 0.5 h / Heating 5: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 6: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 7: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 8: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 9: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
17495-10-2
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2: HCOONH4 / Pd/C / methanol / 4 h / Heating 3: aq. NaOH / 0.5 h / Heating 4: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 5: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 6: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 7: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 8: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
19962-37-9
N-2-乙酰鸟嘌呤
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1.1: 12.6 g / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 2.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 2.2: NH4OH / 1 h / Heating 3.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 4.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 5.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 6.1: aq. NaOH / 0.5 h / Heating 7.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 8.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 9.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 10.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 11.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
39809-25-1
9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 2: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 3: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 4: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 5: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
118-00-3
鸟苷
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1.1: dimethylsulfoxide / 24 h / 20 °C 1.2: 85 percent / aq. HCl / dimethylsulfoxide / 2 h / 70 °C 2.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C 3.1: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C 4.1: HCOONH4 / Pd/C / methanol / 4 h / Heating 5.1: aq. NaOH / 0.5 h / Heating 6.1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 7.1: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 8.1: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 9.1: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 10.1: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
97845-72-2
→
反应条件
104227-87-4
泛昔洛韦
反应条件
1: aq. NaOH / 0.5 h / Heating 2: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 3: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 4: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 5: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 6: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
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