4-氯-3,5-二硝基吡啶合成路线 （共 10 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide 16 h; RefluxInert atmosphere;
参考文献
Organic Letters, , vol. 13, # 3 p. 530 - 533
反应条件
thionyl chloride in N,N-dimethyl-formamide 16 h; Reflux;
参考文献
Chemistry - A European Journal, , vol. 19, # 20 p. 6435 - 6442
反应条件
1: 90 percent / Fuming nitric acid, 30percentoleum / 1)100 deg C,24h,2)140 deg C,124h. 2: 79 percent / PCl5 / POCl3 / 3 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, p. 785 - 791
反应条件
1: sulfuric acid; nitric acid / 96 h / -5 - 130 °C / Inert atmosphere 2: thionyl chloride; N,N-dimethyl-formamide / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 3 p. 530 - 533
反应条件
1: nitric acid; sulfuric acid / 96 h / 130 °C 2: thionyl chloride / N,N-dimethyl-formamide / 16 h / |Reflux View Scheme
参考文献
Chemistry - A European Journal, , vol. 19, # 20 p. 6435 - 6442
反应条件
1: ethyl acetate; phosphorus (III)-chloride 2: N,N-dimethyl-aniline; phosphoryl chloride / 140 °C View Scheme
参考文献
Yakugaku Zasshi, , vol. 72, p. 274
Chem.Abstr., , p. 6416
反应条件
1: N2H4; methanol 2: silver acetate; water View Scheme
参考文献
Kimura; Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 549,551
Chem.Abstr., 1959 , p. 18030
反应条件
in tetrahydrofuran T=0 - 20°C; 1.33333 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2006/122137 A1, 2006 ;
Location in patent: Page/Page column 69-70 ;
WO 2006/122137 A1
反应条件
nitrobenzene
T=195 - 205°C;
参考文献
Ochiai et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 666
Chem.Abstr., 1954 , p. 10746
反应条件
potassium permanganate; ammonia
T=-33°C; 1 h;
参考文献
Wozniak, Marian; Baranski, Andrzej; Szpakiewicz, Barbara
Liebigs Annalen der Chemie, 1993 , # 1 p. 7 - 10
