4-[(叔丁基二甲基甲硅烷基氧基)甲基]苯甲酸合成路线 （共 5 条）
反应条件
1H-imidazole in dichloromethane T=40°C; 8 h;
参考文献
EVOTEC AG; DAVENPORT, Adam James; HALLETT, David James
Patent: WO2010/133544 A1, 2010 ;
Location in patent: Page/Page column 47; 48 ;
WO 2010/133544 A1
反应条件
1: With manganese; NiCl2((PPh3)P)2; tetraethylammonium iodide; triphenylphosphine in 1,3-dimethyl-imidazolidin-2-one T=25°C; P=760.051 Torr; 20 h; 2: With hydrogenchloride; water in diethyl ether T=20°C; 0.166667 h;
参考文献
Fujihara, Tetsuaki; Nogi, Keisuke; Xu, Tinghua; Terao, Jun; Tsuji, Yasushi
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9106 - 9109
反应条件
1: 98 percent / aq. KOH / methanol / Heating 2: 65 percent / imidazole / dimethylformamide View Scheme
参考文献
Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 6 h;
参考文献
EVOTEC AG; DAVENPORT, Adam James; HALLETT, David James
Patent: WO2010/133544 A1, 2010 ;
Location in patent: Page/Page column 48 ;
WO 2010/133544 A1
反应条件
in toluene
T=80°C; Curtius rearrangement; 3 h;
参考文献
Pharmachemie B.V.
Patent: US2009/227617 A1, 2009 ;
Location in patent: Page/Page column 12 ;
