oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 16 h;

oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 2 h;

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 2: palladium diacetate / dichloromethane; diethyl ether / 1 h / 0 - 20 °C 3: lithium hydroxide hydrate / tetrahydrofuran / 0.5 h / 50 °C View Scheme

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 2.1: palladium diacetate / dichloromethane; diethyl ether / 1 h / 0 - 20 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran / 0.5 h / 50 °C 4.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / Reflux 4.2: 16 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C 6.1: hydrogenchloride / water; methanol / 3 h / 20 °C 6.2: pH 8 - 9 View Scheme

AlCl3, aluminium chloride in carbon disulfide T=0°C; 4.5 h; Heating / reflux;