2-甲基-2-苯基-4-戊烯腈合成路线 （共 11 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran; dimethyl sulfoxide
0.666667 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 210-211 ;
WO 2005/030213 A1
反应条件
1: 2-bromo-2-phenylpropionitrile With iso-propylmagnesium bromide in tetrahydrofuran
T=-78°C;
2: allyl bromide in tetrahydrofuran
T=-78°C;
参考文献
Fleming, Fraser F.; Zhang, Zhiyu; Liu, Wang; Knochel, Paul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2200 - 2205
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=25°C; Inert atmosphere; regiospecific reaction;
参考文献
Recio III, Antonio; Tunge, Jon A.
Organic Letters, 2009 , vol. 11, # 24 p. 5630 - 5633
反应条件
potassium hydroxide; Pd(PhCH=CH)2COgt;2CO; 1,2-bis-(diphenylphosphino)ethane in dichloromethane
Ambient temperature;
参考文献
Lebedev, S. A.; Starosel'skaya, L. F.; Petrov, E. S.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 7 p. 1410
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 7 p. 1565 - 1566
反应条件
tetrachloromethane; triethylamine; triphenylphosphine in acetonitrile
Ambient temperature;
参考文献
Walters, Michael A.; Hoem, Andrew B.; McDonough, Colleen S.
Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 55 - 62
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium hydride in dimethyl sulfoxide
T=20°C; 0.5 h; Inert atmosphere;
参考文献
Grenning, Alexander J.; Tunge, Jon A.
Journal of the American Chemical Society, 2011 , vol. 133, # 37 p. 14785 - 14794
反应条件
Bu3SnLi in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
Ambient temperature;
参考文献
Takeda, Takeshi; Ando, Kazuo; Mamada, Akira; Fujiwara, Tooru
Chemistry Letters, 1985 , p. 1149 - 1152
反应条件
1: 84 percent / Br2; PBr3 / 5 h / 60 °C
2: 72 percent / i-PrMgBr / tetrahydrofuran / 2 h
View Scheme
参考文献
Fleming, Fraser F.; Zhang, Zhiyu; Liu, Wang; Knochel, Paul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2200 - 2205
反应条件
2: 60 percent / Ph3P, Et3N, CCl4 / CH2Cl2 / 15 h / Ambient temperature
View Scheme
参考文献
Walters, Michael A.; Hoem, Andrew B.; McDonough, Colleen S.
Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 55 - 62
反应条件
1: 93 percent / butyllithium / tetrahydrofuran / Ambient temperature
2: 92 percent / tributylstannyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature
View Scheme
参考文献
Takeda, Takeshi; Ando, Kazuo; Mamada, Akira; Fujiwara, Tooru
Chemistry Letters, 1985 , p. 1149 - 1152
