(2R,3S,5R)-5-(6-氨基嘌呤-9-基)-2-(羟基甲基)-4-亚甲基四氢呋喃-3-醇合成路线 （共 4 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 3 h;
参考文献
Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7108 - 7113
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.25 h;
参考文献
Usui; Ueda
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1518 - 1523
反应条件
1: 60 percent / CrO3, pyridine, Ac2O / CH2Cl2 2: 1) sodium 2-methyl-2-butoxide / 1) Et2O, benzene, 2h, 2a) -70 to -10 deg C, 1h, 2b) 4 deg C, 48h 3: 99 percent / Bu4NF / tetrahydrofuran / 3 h View Scheme
参考文献
Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7108 - 7113
反应条件
1: 36 percent / pyridine / 48 h / Ambient temperature 2: 60 percent / CrO3, pyridine, Ac2O / CH2Cl2 3: 1) sodium 2-methyl-2-butoxide / 1) Et2O, benzene, 2h, 2a) -70 to -10 deg C, 1h, 2b) 4 deg C, 48h 4: 99 percent / Bu4NF / tetrahydrofuran / 3 h View Scheme
参考文献
Samano, Vicente; Robins, Morris J.
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7108 - 7113
