(2R,5R)-1-(2-(1,3-二氧戊环-2-基)苯基)-2,5-二甲基磷杂环戊烷合成路线 (共 1 条)
反应条件
1: [2-(1,3-dioxolan-2-yl)phenyl]phosphine With potassium tert-butylate in tetrahydrofuran T=-30 - 0°C; 1 h; 2: (4S,7S)-4,7-dimethyl-1,3,2-dioxathiepane 2,2-dioxide in tetrahydrofuran T=20°C; 2 h; 3: With potassium tert-butylate in tetrahydrofuran T=20°C; 48 h; Further stages.;
参考文献
Bonnaventure, Isabelle; Charette, Andre B.
Journal of Organic Chemistry, 2008 , vol. 73, # 16 p. 6330 - 6340