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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1044596-95-3
合成路线
(共 4 条)
1044596-95-3
→
反应条件
760173-05-5
(R)-5-(2-氨基乙基)-1-(6,8-二氟苯并二氢吡喃-3-基)-1,3-二氢咪唑-2-硫酮
反应条件
sodium tetrahydroborate in dichloromethane; water; isopropyl alcohol T=20 - 25°C; 16 h;
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
1043421-43-7
→
反应条件
1044596-95-3
反应条件
Multi-step reaction with 6 steps 1: sulfuric acid / acetic acid / 1 h / 100 °C2: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C3: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr4: water; potassium hydroxide / methanol / 24 h / Reflux5: ethanol; water / 1 h / 20 °C6: acetic acid / 2 - 4 h / 100 °C
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
1151797-94-2
→
反应条件
1044596-95-3
反应条件
Multi-step reaction with 5 steps 1: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C2: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr3: water; potassium hydroxide / methanol / 24 h / Reflux4: ethanol; water / 1 h / 20 °C5: acetic acid / 2 - 4 h / 100 °C
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
1044596-89-5
→
反应条件
1044596-95-3
反应条件
Multi-step reaction with 7 steps 1: sodium hydroxide / water / 1 h / 0 - 5 °C2: phosphorus pentachloride / dichloromethane / 1 h / 0 - 5 °C3: AlCl3, aluminium chloride / dichloromethane / 4 h / 3 - 8 °C4: Pearlman's catalist; sulfuric acid; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 5171.62 Torr5: water; potassium hydroxide / methanol / 24 h / Reflux6: ethanol; water / 1 h / 20 °C7: acetic acid / 2 - 4 h / 100 °C
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709