(S)-吡咯烷-2-乙酸叔丁酯合成路线 （共 11 条）
反应条件
hydrogen; acetic acid; palladium dihydroxide in methanol T=20°C; P=760 Torr;
参考文献
Synlett, , # 7 p. 1146 - 1148
反应条件
hydrogen; palladium dihydroxide in methanol P=3800 Torr; 16 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 7 p. 1284 - 1301
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C 1.2: 79 percent / tetrahydrofuran / 2 h / -78 °C 2.1: 87 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1.33 h / -78 - 20 °C 3.1: 96 percent / H2 / Pd(OH)2/C / methanol / 16 h / 3800 Torr View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 7 p. 1284 - 1301
反应条件
1: 69 percent / n-butyllithium / tetrahydrofuran / -78 °C 2: 77 percent / PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 12 h / Heating 3: 86 percent / H2 / RhCl(PPh3)3 / benzene / 20 °C / 1520 Torr 4: 92 percent / H2; acetic acid / 20 percent Pd(OH)2 on C / methanol; H2O / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3253 - 3265
反应条件
1: 77 percent / PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 12 h / Heating 2: 86 percent / H2 / RhCl(PPh3)3 / benzene / 20 °C / 1520 Torr 3: 92 percent / H2; acetic acid / 20 percent Pd(OH)2 on C / methanol; H2O / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3253 - 3265
反应条件
1: 86 percent / H2 / RhCl(PPh3)3 / benzene / 20 °C / 1520 Torr 2: 92 percent / H2; acetic acid / 20 percent Pd(OH)2 on C / methanol; H2O / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3253 - 3265
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C 1.2: 7 percent / tetrahydrofuran / 4 h / -78 - -20 °C 2.1: 96 percent / H2 / Pd(OH)2/C / methanol / 16 h / 3800 Torr View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 7 p. 1284 - 1301
反应条件
1: 87 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1.33 h / -78 - 20 °C 2: 96 percent / H2 / Pd(OH)2/C / methanol / 16 h / 3800 Torr View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 7 p. 1284 - 1301
反应条件
1: 62 percent / n-butyllithium / tetrahydrofuran / -78 °C 2: 76 percent / PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 12 h / Heating 3: 86 percent / H2 / RhCl(PPh3)3 / benzene / 20 °C / 1520 Torr 4: 92 percent / H2; acetic acid / 20 percent Pd(OH)2 on C / methanol; H2O / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3253 - 3265
反应条件
1: 76 percent / PhCH=Ru(PCy3)2Cl2 / CH2Cl2 / 12 h / Heating 2: 86 percent / H2 / RhCl(PPh3)3 / benzene / 20 °C / 1520 Torr 3: 92 percent / H2; acetic acid / 20 percent Pd(OH)2 on C / methanol; H2O / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3253 - 3265
