N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-脱氧-5-甲基胞苷合成路线 （共 17 条）
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 18 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2003/232434 A1, 2003 ;
Location in patent: Page 17-18 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 18 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/5706 A1, 2004 ;
Location in patent: Page/Page column 17 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 18 h;
参考文献
Freier, Susan M.; Dobie, Kenneth W.; Bhanot, Sanjay
Patent: US2004/77570 A1, 2004 ;
Location in patent: Page/Page column 17-18 ;
反应条件
in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/29272 A1, 2004 ;
Location in patent: Page/Page column 17-18 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 18 h;
参考文献
Isis Pharmaceuticals Inc.
Patent: US2004/23382 A1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
triethanolamine in dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile
参考文献
Eldrup, Anne B.; Cook, Phillip Dan; Parshall, B. Lynne
Patent: US2004/14108 A1, 2004 ;
反应条件
1: 5-Methyl-2'-deoxycytidine; benzoic acid anhydride in DMF (N,N-dimethyl-formamide)
T=40°C; 5 h;
2: 4,4'-dimethoxytriphenylmethyl chloride With pyridine in DMF (N,N-dimethyl-formamide)
T=10°C; 15 h;
3: With sodium hydroxide; sodium hydrogencarbonate
Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: US2005/192433 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
in pyridine
2 h; Ambient temperature;
参考文献
Uesugi; Miyashiro; Tomita; Ikehara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 51 - 60
反应条件
potassium tert-butylate in toluene
T=20°C; 39 h;
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1.1: 93 percent / pyridine / 1.5 h / 20 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 0 °C
2.2: 1,2,4-triazole; phosphorous oxycloride / acetonitrile / -20 - 0 °C
2.3: 85 percent / aq. ammonium hydroxide / dioxane / 1 h
3.1: dimethylformamide / 22 h / 20 °C
4.1: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
