N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-脱氧-5-甲基胞苷合成路线 （共 17 条）
反应条件
1: dimethylformamide / 22 h / 20 °C
2: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 0 °C
1.2: 1,2,4-triazole; phosphorous oxycloride / acetonitrile / -20 - 0 °C
1.3: 85 percent / aq. ammonium hydroxide / dioxane / 1 h
2.1: dimethylformamide / 22 h / 20 °C
3.1: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1: dimethylformamide / 22 h / 20 °C
2: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1.1: 93 percent / pyridine / 1.5 h / 20 °C
2.1: trimethylsilyl chloride; triethylamine / acetonitrile / -10 - 0 °C
2.2: 1,2,4-triazole; phosphorous oxycloride / acetonitrile / -20 - 0 °C
2.3: 85 percent / aq. ammonium hydroxide / dioxane / 1 h
3.1: dimethylformamide / 22 h / 20 °C
4.1: 1460 g / potassium tert-butoxide / toluene / 39 h / 20 °C
View Scheme
参考文献
Ross, Bruce; Han, Mingming; Ravikumar, Vasulinga
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 765 - 770
反应条件
1: (PhO)2POCl, Et3N / dioxane
2: NH3 / CHCl3 / 3 h / 20 °C
3: C5H5N / 3 h / 20 °C
4: hydrazine, C5H5N / acetic acid / 0.05 h / 20 °C
View Scheme
参考文献
Marel, G. A. van der; Wille, G.; Westerink, H.; Wang, A. H.-J.; Rich, A.; et al.
Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 2 p. 77 - 78
反应条件
1: 73 percent / pyridine / 1.) 0 deg C, 10 min; 2.) r.t., 3 h
2: 71 percent / pyridine / 2 h / Ambient temperature
View Scheme
参考文献
Uesugi; Miyashiro; Tomita; Ikehara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 51 - 60
反应条件
1: 73 percent / pyridine / 1.) 0 deg C, 10 min; 2.) r.t., 3 h
2: 71 percent / pyridine / 2 h / Ambient temperature
View Scheme
参考文献
Uesugi; Miyashiro; Tomita; Ikehara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 51 - 60
