(R)-2-((4-氟苯氧基)甲基)环氧乙烷合成路线 （共 6 条）
反应条件
1: 4-Fluorophenyl alcohol With potassium carbonate in butanone T=20°C; 0.166667 h; Inert atmosphereSchlenk technique; 2: (R)-(-)-epichlorohydrin in butanone T=90°C; 15 h; Inert atmosphereSchlenk technique;
参考文献
Park, Jung-Eun; Ji, Wan Keun; Jang, Jae Wan; Pae, Ae Nim; Choi, Keehyun; Choi, Ki Hang; Kang, Jahyo; Roh, Eun Joo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1887 - 1890
反应条件
sodium periodate; sodium sulfate in hexane; dichloromethane; sodium hydrogencarbonate; ethyl acetate
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US6310221 B1, 2001 ;
反应条件
Salen-Co(III)OAc in water Ambient temperature;
参考文献
Gurjar, Mukund K.; Sadalapure, Kashinath; Adhikari, Susanta; Sarma, Bugga V. N. B. S.; Talukdar, Arindam; Chorghade, Mukund S.
Heterocycles, 1998 , vol. 48, # 7 p. 1471 - 1476
反应条件
1.1: 84 percent / K2CO3 / acetone / 6 h / Heating 2.1: 46 percent / (R,R)-(salen)Co(III)(OAc) / H2O; various solvent(s) / 6 h / 20 °C 3.1: TMSCl; CH3C(OMe)3 / CH2Cl2 / 1 h / 0 °C 3.2: 91 percent / K2CO3 / methanol / 2 h / 20 °C View Scheme
参考文献
Gurjar, Mukund K.; Murugaiah; Radhakrishna; Ramana; Chorghade, Mukund S.
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1363 - 1370
反应条件
1.1: 46 percent / (R,R)-(salen)Co(III)(OAc) / H2O; various solvent(s) / 6 h / 20 °C 2.1: TMSCl; CH3C(OMe)3 / CH2Cl2 / 1 h / 0 °C 2.2: 91 percent / K2CO3 / methanol / 2 h / 20 °C View Scheme
参考文献
Gurjar, Mukund K.; Murugaiah; Radhakrishna; Ramana; Chorghade, Mukund S.
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1363 - 1370
反应条件
caesium carbonate in acetonitrile Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
