2-(4-羟基环己基)异吲哚-1,3-二酮合成路线 （共 7 条）
反应条件
potassium carbonate in tetrahydrofuran; water T=20°C; 72 h;
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
Location in patent: Page/Page column 62 ;
反应条件
0.0833333 h; Heating;
参考文献
Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen
Patent: US2008/269193 A1, 2008 ;
Location in patent: Page/Page column 33 ;
反应条件
potassium carbonate in water T=20°C; 1 h;
参考文献
NOVO NORDISK A/S
Patent: WO2007/115935 A1, 2007 ;
Location in patent: Page/Page column 61 ;
反应条件
pyridinium p-toluenesulfonate in N,N-dimethyl-formamide; toluene 15 - 17 h; Heating / reflux; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED
Patent: WO2006/3677 A1, 2006 ;
Location in patent: Page/Page column 10; 15 ;
参考文献
Dr. Karl Thomae GmbH
Patent: US4731374 A1, 1988 ;
反应条件
1: triethylamine / 4 h / 0 - 20 °C 2: potassium carbonate / water / 2 h / 20 °C View Scheme
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
WO 2013/013188 A1
反应条件
sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hydrogencarbonate; sodium bromide in ethyl acetate T=5 - 20°C; pH=7 - 8;
参考文献
CHIRAL QUEST, INC.; WEI, Yuan; LI, Tianqiao; CHI, Yongxiang; ZHU, Jingyang
Patent: WO2010/78250 A1, 2010 ;
Location in patent: Page/Page column 12 ;
