N-(4-氧代环己基)酞酰亚胺合成路线 （共 11 条）
反应条件
sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hydrogencarbonate; sodium bromide in ethyl acetate T=5 - 20°C; pH=7 - 8;
参考文献
CHIRAL QUEST, INC.; WEI, Yuan; LI, Tianqiao; CHI, Yongxiang; ZHU, Jingyang
Patent: WO2010/78250 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; water T=115°C; 2 h;
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
Location in patent: Page/Page column 59 ;
反应条件
4 A molecular sieve; pyridinium chlorochromate in dichloromethane 3 h;
参考文献
Glennon, Richard A.; Hong, Seoung-Soo; Bondarev, Mikhail; Law, Ho; Dukat, Malgorzata; Rakhit, Suman; Power, Patricia; Fan, Ermei; Kinneau, Diana; Kamboj, Rajender; Teitler, Milt; Herrick-Davis, Katharine; Smith, Carol
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322
反应条件
1: 86 percent / aq. K2CO3 / 0.5 h / Ambient temperature 2: 95 percent / PCC, molecular sieves 4A / CH2Cl2 / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 314 - 322
反应条件
1: 86 percent / aq. K2CO3 / 0.5 h / Ambient temperature 2: 95 percent / PCC, molecular sieves 4A / CH2Cl2 / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 314 - 322
反应条件
2: 67 percent / pyridinium chlorochromate View Scheme
参考文献
Journal of medicinal chemistry, , vol. 36, # 13 p. 1918 - 1919
反应条件
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 2: toluene-4-sulfonic acid / water; tetrahydrofuran / 2 h / 115 °C View Scheme
反应条件
1: sodium tetrahydroborate; methanol / 2 h / 20 °C 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C 3: toluene-4-sulfonic acid / water; tetrahydrofuran / 2 h / 115 °C View Scheme
反应条件
bromine; AlCl3, aluminium chloride in methanol; ethyl acetate T=0°C; 0.166667 - 0.25 h; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED
Patent: WO2006/3677 A1, 2006 ;
Location in patent: Page/Page column 10; 17 ;
反应条件
bromine in ethanol T=5 - 78°C; 8 h;
参考文献
WO2008/41240 A1, ;
Page/Page column 16-17 ;
