4-羟基-3-硝基苯乙酸合成路线 （共 17 条）
反应条件
nitric acid; acetic acid 5 deg C, 1 h -> room temperature, 1 h;
参考文献
Huegel, Helmut M.
Synthetic Communications, 1985 , vol. 15, # 12 p. 1075 - 1080
反应条件
sodium peroxynitrite in phosphate buffer T=20 - 25°C; Nitration; hydroxylation; pH=7.0; Kinetics; Further Variations:Solvents;
参考文献
Tetrahedron Letters, , vol. 40, # 38 p. 6933 - 6937
反应条件
hydrogen; sodium hydrogencarbonate; palladium on activated charcoal P=3102.9 Torr; 4 h;
参考文献
Huegel, Helmut M.
Synthetic Communications, 1985 , vol. 15, # 12 p. 1075 - 1080
反应条件
in N,N-dimethyl-formamide
参考文献
Kori, Masakuni; Miki, Takashi; Nishimoto, Tomoyuki; Tozawa, Ryuichi
Patent: US2003/78251 A1, 2003 ;
反应条件
1: sulfuric acid / 70 °C / |Reflux 2: potassium carbonate / 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
in acetonitrile 1 h; Yield given;
参考文献
Sviridov, S. I.; Ermolinskii, B. S.
Chemistry of Natural Compounds, 1990 , vol. 26, # 6 p. 691 - 696
Khimiya Prirodnykh Soedinenii, 1990 , # 6 p. 811 - 818
反应条件
1: 90 percent / HCl / Heating 2: 92 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
hydrogenchloride in water Heating / reflux;
参考文献
OXFORD GLYCOSCIENCES (UK) LTD
Patent: WO2004/46122 A2, 2004 ;
Location in patent: Page 15 ;
反应条件
sodium hydrogencarbonate in methanol; toluene
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
in diethyl ether Yield given;
参考文献
Sviridov, S. I.; Ermolinskii, B. S.
Chemistry of Natural Compounds, 1990 , vol. 26, # 6 p. 691 - 696
Khimiya Prirodnykh Soedinenii, 1990 , # 6 p. 811 - 818
