3-甲酰基-3,4-二氢-1H-异喹啉-2-羧酸叔丁酯合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.25 h;
参考文献
Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu
Patent: US2004/82590 A1, 2004 ;
Location in patent: Page/Page column 58 ;
US 20040082590 A1
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 0°C; 0.833333 h;
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
反应条件
borane in tetrahydrofuran
参考文献
McMills, Mark C.; Wright, Dennis L.; Zubkowski, Jeffrey D.; Valente, Edward J.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7205 - 7208
反应条件
1: 99 percent / NaOH / 2-methyl-propan-2-ol; various solvent(s) / 12 h / 20 °C 2: 98 percent / borane-THF complex / tetrahydrofuran / 0 - 20 °C 3: 90 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.83 h / -78 - 0 °C View Scheme
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
1: 99 percent / NaOH / 2-methyl-propan-2-ol; various solvent(s) / 12 h / 20 °C 2: 98 percent / borane-THF complex / tetrahydrofuran / 0 - 20 °C 3: 90 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.83 h / -78 - 0 °C View Scheme
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
反应条件
1: 96 percent / triethylamine / CH2Cl2 2: 87 percent / triethylamine; SO3*pyridine; DMSO / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
1: 99 percent / NaOH 2: 98 percent / BH3 / tetrahydrofuran View Scheme
参考文献
McMills, Mark C.; Wright, Dennis L.; Zubkowski, Jeffrey D.; Valente, Edward J.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7205 - 7208
