反应条件
1.1: 77 percent / EEDQ / CHCl3 / 2 h / 20 °C
2.1: 87 percent / DIPEA / dimethylformamide / 0.17 h
3.1: NaH / tetrahydrofuran / 0.17 h
3.2: 78 percent / tetrahydrofuran / 0.5 h
4.1: 95 percent / TBAF / tetrahydrofuran / 0.25 h
5.1: 68 percent / triphenylphosphine; carbon tetrabromide / CH2Cl2 / 1 h
6.1: 179 mg / potassium carbonate / dimethylformamide / 16 h / 20 °C
View Scheme
参考文献
Jeffrey, Scott C.; Torgov, Michael Y.; Andreyka, Jamie B.; Boddington, Laura; Cerveny, Charles G.; Denny, William A.; Gordon, Kristine A.; Gustin, Darin; Haugen, Jennifer; Kline, Toni; Nguyen, I Minh T.; Senter, Peter D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1344 - 1358
