1,1'-联(环己烷)-1'-烯-2-胺合成路线 （共 35 条）
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / 0 °C
1.2: tetrahydrofuran / 0.67 h / -18 °C
2.1: 485 mg / oxalic acid / tetrahydrofuran; H2O / 6 h / 27 °C
3.1: 29 percent / bis(triphenylphosphine)palladium(II) dichloride; cesium carbonate / tetrahydrofuran / 14 h / 100 °C
View Scheme
参考文献
Muratake, Hideaki; Natsume, Mitsutaka; Nakai, Hiroshi
Tetrahedron, 2004 , vol. 60, # 51 p. 11783 - 11803
反应条件
1: 1.) LDA / 1.) THF, hexane, from -78 to 0 deg C, 3 h, 2.) THF, hexane, RT, 2 h
2: 1M aq. HCl / diethyl ether / 2 h / Heating
View Scheme
参考文献
Trost, Barry M.; Chen, Deborah W. C.
Journal of the American Chemical Society, 1996 , vol. 118, # 50 p. 12541 - 12554
反应条件
1: (i) LDA, 1,10-phenanthroline, (ii) /BRN= 1737987/, (iii) oxalic acid
2: KOH / ethanol / Heating
View Scheme
参考文献
Jacobson,R.M. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 15 p. 2545 - 2549
反应条件
Multi-step reaction with 2 steps 1: 1.) triethylamine / 1.) acetonitrile, 25-30 deg C (30 min), room temperature (1h), 2.) reflux, 2.6-4.0 kPa2: 84 percent / Pd/C / 1,3,5-trimethyl-benzene / 24 h / Heating
参考文献
Madsen, J.Oe.; Meldal. M.; Mortensen. S.; Olsson, B. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981 , vol. 35, # 2 p. 77 - 82
反应条件
Multi-step reaction with 2 steps 2: via 2,6-dibromo derivative
参考文献
Utaka, Masanori; Watabu, Hisashi; Takeda, Akira Chemistry Letters, 1985 , p. 1475 - 1476
