5,6-二氨基吡啶-3-羧酸甲酯合成路线 （共 7 条）
反应条件
hydrogen; Raney Nickel in methanol; water
T=80°C; P=2068.65 Torr; 5 h;
参考文献
UNIVERSITE DE MONTREAL; RUEL, Rejean; CHANTIGNY, Yves; MARINIER, Anne; RENE, Patricia; BOUVIER, Michel
Patent: WO2012/3576 A1, 2012 ;
Location in patent: Page/Page column 100 ;
WO 2012/003576 A1
反应条件
hydrazine; nickel in methanol
0.25 h; Heating;
参考文献
Zimmermann, Peter Jan; Buhr, Wilm; Brehm, Christof; Palmer, Andreas Marc; Feth, Martin Philipp; Senn-Bilfinger, Joerg; Simon, Wolfgang-Alexander
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 19 p. 5374 - 5378
反应条件
sodium carbonate in methanol hydrochloric acid
参考文献
Barrow, James C.; Coburn, Craig; Selnick, Harold G.; Ngo, Phung L.
Patent: US2002/193398 A1, 2002 ;
US 20020193398 A1
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4738970 A1, 1988 ;
反应条件
1.1: nitric acid; sulfuric acid / 1.83 h / 0 - 20 °C
1.2: 1.5 h / 100 °C
1.3: 0 °C / pH 2
2.1: sulfuric acid / 5 h / 0 - 60 °C
3.1: hydrogen / Raney Nickel / water; methanol / 5 h / 80 °C / 2068.65 Torr
View Scheme
参考文献
UNIVERSITE DE MONTREAL; RUEL, Rejean; CHANTIGNY, Yves; MARINIER, Anne; RENE, Patricia; BOUVIER, Michel
Patent: WO2012/3576 A1, 2012 ;
WO 2012/003576 A1
反应条件
1: sulfuric acid / 5 h / 0 - 60 °C
2: hydrogen / Raney Nickel / water; methanol / 5 h / 80 °C / 2068.65 Torr
View Scheme
参考文献
UNIVERSITE DE MONTREAL; RUEL, Rejean; CHANTIGNY, Yves; MARINIER, Anne; RENE, Patricia; BOUVIER, Michel
Patent: WO2012/3576 A1, 2012 ;
WO 2012/003576 A1
参考文献
Merck and Co., Inc.
Patent: US6610692 B1, 2003 ;
US 6610692 B1
